Dr. Eric Kmiec believes innovators don’t decide whether an idea is worth pursuing. The data decides.

“I’ve seen many people promote their data where they wanted it to work so badly, it consumes them, drives them into sloppy science and they end up stumbling scientifically,” says the executive director and chief scientific officer of the ChristianaCare Gene Therapy Institute and CEO of CorriXR Therapeutics, the biotech spinout whose initial focus is oncology.

“Their enthusiasm cloaks the truth; they design experiments solely to make their innovation look better, rather than doing the tougher controls to evaluate their hypothesis and try to disprove it. That’s the essence of science. I was once told by the president of the National Academy of Sciences: ‘The truth always comes out in science. Better to be early to that game than to be late.’”

Dr. Kmiec is known throughout the scientific community for his pioneering work in the fields of molecular medicine and gene editing, which is a group of technologies that enable scientists to change an organism’s DNA. He has researched and developed CRISPR-based genetic therapies for sickle cell disease and non-small cell lung cancer. He holds faculty appointments at the University of Delaware and the Wistar Institute in Philadelphia and has been a National Institute of Health and National Science Foundation-supported principal investigator for 34 years.

He recently shared his views on innovation in Delaware and the path forward for innovators.

One of the great advantages of a state the size of Delaware is, frankly, the size of Delaware. There are a lot of collateral and productive interactions occurring daily that provide access to government officials, CEOs and state and county committees that can help guide your thoughts surrounding innovation. There are certainly advantages baked into coming from an ecosystem where there are hundreds of startups, but in those situations, you almost must be a distinct yet mature program to receive the appropriate attention to develop your innovative ideas. By contrast, here in Delaware, you can get in to see people who can evaluate the probability of success and even give you some advice on the return on investment. The state has also dedicated itself to expanding the availability of lab space for not only startups but for mezzanine-level companies and encouraging new real estate projects throughout the state for those of us who seek to expand our operations.

Relentlessness and a long-term belief in your ideas. I experienced a great deal of pushback in the early years of gene editing where many people believed it was just a fantasy and would never happen. I was also told that in vivo (in living cells) delivery would never occur and the whole idea of introducing biotherapeutics into the body was a dead end. Now, they are the biggest fans of the Gene Editing Institute.

Take your time and understand that excellent scientific ideas are often incremental advances that often do not translate into the world of application. In fact, if you are trained properly in science, you are taught to develop incremental advances, and once you or your colleagues cobble together a number of those incremental advances, you will have something that could be a significant step forward. But it takes time, and we are by design impatient, so one of the greatest flaws is that we want to push things forward because we “know” it’s right. That’s a deadly mistake. Be resolute in your belief, but also look to solve a fundamental but rather simple problem first.

I learned a hard lesson in the early days of gene editing. Good ideas need time to mature, and good things await those who are patient. As frustrating and painful and methodical as it might be, researchers must establish a foundational base for their idea. If that idea survives the constant multi-dimensional probing, then that idea will be the one worth pursuing. In addition, you need to understand that negative feedback is far more important than positive feedback.

I had to learn to be patient through the years and pioneered a lot of gene editing concepts early on. I’m still here to watch the field emerge and do great things. It’s a rewarding space for me now. Looking back, CRISPR was actually identified and studied intently in the mid-1980s, and some could argue today that those early scientists who understood the microbiology of milk fermentation actually helped in the discovery of CRISPR and they should have been part of the Nobel Prize in Chemistry awarded in 2020. It was their work that enabled Jennifer Doudna and Emmanuelle Charpentier to translate its use into human cells and the rest, as they say, is history.

I’ve also found that new innovators immediately want to start a company thinking that raising money is easy and that once they mature it for a while, they’ll become wealthy. Sadly, it doesn’t work like that.

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Eric Smith has known since he was 15 that he wanted to support entrepreneurs and business owners like his dad. Now 31, he’s doing just that through Wilmington-based Launch Point Labs – one of Delaware’s first startup studios that is also building an early-stage venture fund. Smith started Launch Point Labs in 2021 after stepping down as vice president at Carvertise, the Wilmington-based advertising company he helped build into a multi-million-dollar company.

Launch Point Labs provides small businesses and nonprofits access to a team of sales professionals, content creators, brand strategists, and project managers. The goal is to help entrepreneurs gain traction in their businesses while also providing financial help through a $5 million fund the company is building to invest directly in promising companies.

Launch Point Labs, which has been working to launch multiple Delaware companies in 2022, helps startups for free out of the gate. Once the startup is profitable, it can become a paying client with access to LPL resources through either a monthly fee or equity.

Here are Smith’s views on innovation in Delaware and his advice to hungry innovators.

Delaware is a fantastic place to start a business and is becoming a hotbed of entrepreneurship. The First State has a favorable business climate, a long history of assisting businesses and an excellent track record for supporting entrepreneurs.

The state provides a great environment for small businesses, which have provided the majority of jobs in the state (and are vital for economic growth). The state also has a strong background in science and technology, which has led to a vibrant economy and a strong environment for entrepreneurs.

The biggest thing I would tell any entrepreneur is to keep his or her eyes on the long-term goal. Every day, you must do something that will advance your business, but it’s important to understand that it’s a journey, not a destination. You must keep moving forward and take small steps that add up over time. Be patient. The process of building a company is long, difficult and often frustrating. It takes a lot of hard work, and the payoff is often years in the future. Focus on building a strong foundation and keep plugging away.

The most successful innovators are those who are passionate about their ideas, constantly learning new skills and seeking new ways to improve their businesses. They are also ones who are patient, keep moving forward and are flexible enough to change course when needed.

It takes a lot of drive and determination to keep pushing forward when the going gets tough. It also takes a strong work ethic and the ability to turn criticism into fuel to keep moving forward.

You must be creative, determined and strategic. The best innovators know that the journey is a long-term one, not a get-rich-quick scheme, so you must be comfortable being patient while you build your business.

As a leader, it’s critical to have a process for deciding which new ideas to pursue and which to set aside. In the heat of the moment, it can be hard to separate the good ideas that should be expanded from the bad ones that should be cut. This can lead to a lot of wasted time and energy, and result in the same old status quo instead of the innovation the company needs. Receiving feedback and customer validation is key to determining if an idea is worth pursuing. Before you start turning your idea into a product/service, make sure you ask potential users/customers if they’re willing to use (and pay for) your idea. If yes, then what they say will reinforce your beliefs and direct you on what to do next. If no, then you must be ready to back out and try something else.

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In this series, Delaware leaders noted for innovation share insights on innovation. Incyte, the Delaware-based global biopharma leader, has experienced significant growth and expansion over the last two decades in its work to discover, develop and deliver breakthrough medicines for cancer, inflammatory, and autoimmunity diseases. President, Chief Executive Officer, and Chair of the Board Hervé Hoppenot shares what makes Delaware the ideal place for innovation. He also reflects on the importance of resilience, tenacity, and collaboration, especially when it comes to creating a dynamic environment that breeds innovations.

HH: At Incyte, we are happy to call Delaware home. Our roots go back to 2002 when we were founded by a small group of scientists who believed Delaware was the right place for drug discovery and development. Over the last two decades, we have received significant support from local leaders, which has helped facilitate our continued growth and expansion in the region, including a new state-of-the-art research facility that was opened this year. As the community in Delaware meaningfully embraces our work, we continue to innovate and are discovering and developing new medicines for patients right here in Wilmington. We are also driven to give back to this community that has given so much to us, and we are proud to have recently announced a five-year extension of the Incyte Cancer Care Assistance Fund for Delaware, which has provided financial assistance for Delaware cancer patients, their caregivers and family members since its inception in 2018.

HH: We believe the most powerful innovation comes from resiliency, tenacity and collaboration around a shared purpose. At Incyte, we exist to find meaningful, new solutions for patients around the world living with serious unmet medical needs. Everyone here – the Executive Team, scientists and administrators – all play a role in advancing our ability to find new solutions that can positively affect these patients’ lives. Beyond this, we believe successful innovation requires the sharing of ideas. Innovation happens when people mix. Our exceptional team of biologists and chemists work side-by-side in our labs each day and are just steps away from colleagues who help ensure our medicines get to patients who need them. This dynamic environment allows our employees to listen to and engage with one another, which helps us all breed innovation.

HH: Innovators must realize that challenges will come – there will be bad days and setbacks. However, breakthroughs take time and require patience. It is important to always keep the end goal in mind – approaching each day with resiliency and tenacity while seeking to make the world a better place. Additionally, innovators must surround themselves with inspiration and whatever tools are needed to achieve their goals. Innovation does not happen in a vacuum. At Incyte, we try to provide the environment innovators need to succeed. Oftentimes, it requires working cohesively with others toward a common goal.

Hervé Hoppenot joined Incyte in 2014 as President and Chief Executive Officer and was appointed Chairman of the Board of Directors in 2015.

During Mr. Hoppenot’s tenure, the company has tripled the number of clinical candidates in its portfolio, expanding beyond Oncology to include research and development in Inflammation & Autoimmunity. Under his leadership, revenue has increased by nearly 600%. With a goal to deliver medicines to patients worldwide, Incyte has expanded geographically and has operations in North America, Europe and Asia.

Prior to joining the global biopharma leader Incyte, Mr. Hoppenot was the President of Novartis Oncology. Before joining Novartis in 2003, Mr. Hoppenot started his career in 1983 with Rhone Poulenc, later known as Aventis, where he served in several senior roles of increasing responsibility, including Vice President of Oncology and Head of the U.S. Oncology business unit. Mr. Hoppenot holds a diploma from ESSEC Business School.

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